姓名：嚴志祥
職稱： 副研究員 電話： 0756-252-8106 電子郵件： yanzhx3@mail.sysu.edu.cn 通訊地址： 珠海市香洲區梅華東路52號，中山大學附屬第五醫院
職稱： 副研究員 電話： 0756-252-8106 電子郵件： yanzhx3@mail.sysu.edu.cn 通訊地址： 珠海市香洲區梅華東路52號，中山大學附屬第五醫院
2012/08-2015/12 澳門大學，生物醫藥，博士
2009/09-2012/06 南京師范大學，微生物與生化藥學，碩士
2005/09-2009/07 南京師范大學，生物技術，學士
2018/07-至今 中山大學附屬第五醫院，副研究員
2016/05-2018/05 澳門大學，中華醫藥研究院，博士后
1. 多組學（蛋白組、代謝組、脂質組、微生物組）質譜分析新方法的開發；
2. 多組學大數據分析和生物信息學新方法的開發；
3. 多組學技術研究微生物（腸道菌）與宿主的相互作用；
4. 多組學技術研究心血管疾病、腫瘤等重大疾病的發病機制；
1. 國家自然科學基金青年科學基金項目， 31900070，基于代謝組學和宏蛋白質組學解析潰瘍性結腸炎腸道菌群代謝變化及機制，2020/01-2022/12，主持，
2. 廣東省自然科學基金-面上項目，腸道菌群與宿主甾體代謝基于β-glucuronidase/glucuronide軸的相互關聯，2019A1515011771，2019/10.-2022/09，主持
3. 中山大學“百人計劃”引進人才科研啟動經費，2018/07-2021/07，主持
4. 南方海洋科學與工程廣東省實驗室（珠海）自主科研項目，SML2020SP003，海洋環境下人體代謝網絡調控，2020/11-2023/10，第一參與人
1. 與澳門大學新冠科技攻關合作項目，新型冠狀病毒感染的非侵入性代謝組學診斷技術研究，合作申請
1. Yan ZX*, He FX, Xiao F, He HH, Li D, Cong L, Lin L, Zhu HJ, Wu YY, Yan R*, Li XF*, Shan H*. A semi-tryptic peptide centric metaproteomic mining approach and its potential utility in capturing signatures of gut microbial proteolysis. Microbiome 2021, 9, 12.
2. Yan ZX*, He FX, He HH, Li D, Pang, PF, Fang ZX, Jiang GM, Huang SW, Li KX, Gu ZQ, Shi HG, Zhang ZY, Zhu HJ , Lin L, Li JL, Yan R*, Xiao F *, Li XF *, Shan H*. Molecular phenomics of gut ecosystem in COVID-19 patients. (https://www.researchsquare.com/article/rs-208797/v1) Microbiome (under review)
3. Lin L#, Jiang X#, Zhang Z, Huang S, Zhang Z, Fang Z, Gu Z, Gao L, Shi H, Mai L, Liu Y, Lin X, Lai R, Yan ZX*, Li X*, Shan H*. Gastrointestinal Symptoms of 95 Cases with SARS-CoV-2 Infection. Gut 2020, 69(6):997-1001.
4. Yan ZX, Yan R*. Exploring the potential of data-independent acquisition proteomics using untargeted all-ion quantitation: application to tumor subtype diagnosis. Analytical Chemistry (2018) 90, 4380-4388.
5. Yan ZX, Yan R*. Improved data-dependent acquisition for untargeted metabolomics using gas-phase fractionation with staggered mass range. Analytical Chemistry (2015) 87, 2861-2868.
6. Yan ZX, Yan R*. Increase the accessibility and scale of targeted metabolomics: construction of a human urinary metabolome-wide multiple reaction monitoring library using directly-coupled reversed-phase and hydrophilic interaction chromatography. Analytica Chimica Acta (2015) 894, 65-75.
7. Yan ZX, Lin G, Ye Y, Wang YT, Yan R*. Triterpenoid saponins profiling by adducts-targeted neutral loss triggered enhanced resolution and product ion scanning using triple quadrupole linear ion trap mass spectrometry. Analytica Chimica Acta (2014) 819, 56-64.
8. Yan ZX#, Gao XJ#, Li T, Wei B, Wang PP, Yang Y, Yan R*. Fecal microbiota transplantation in experimental ulcerative colitis reveals associated host metabolic and gut bacterial reprogramming. Applied and Environmental Microbiology (2018) 84(14), pii: e00434-18.
9. Yan ZX, Yan R*. Tailored sensitivity reduction improves pattern recognition and information recovery with a higher tolerance to varied sample concentration for targeted urinary metabolomics. Journal of Chromatography A (2016) 22, 101-110.
10. Yan ZX, Lin G, Ye Y, Wang YT, Yan R*. A generic multiple reaction monitoring based approach for flavonoids profiling in plants using a hybrid triple quadrupole linear ion trap mass spectrometry. Journal of the American Society for Mass Spectrometry. (2014) 25, 955-965.
1. The 6th Asia Pacific ISSX Meeting, May 11-14, 2018. Hangzhou, China. Best Poster Award First Prize.
2. The 11th Annual International Conference of the Metabolomics Society, June 29-July 2, 2015. San Francisco Burlingame, USA. Travel Award.
3. The 12th Consortium for Globalization of Chinese Medicine (CGCM), August 27-29, 2013. Graz, Austria. Travel Award.
4. The 4th Annual Symposium on Clinical and Pharmaceutical Solutions through Analysis (CPSA). April 24-27, 2013. Shanghai, China. Innovator Award.
